Increased p53 expression under the endogenous promoter protects “super p53” mice from tumorigenesis without the undesirable effects of premature aging.
>Garcia-Cao and collaborators report the generation of novel transgenic mice, called “super p53.” The super p53 mice express wild-type endogenous p53, and also carry one or two extra copies of a normal p53 gene, inserted as transgenes in the form of large genomic fragments of 130 to 175 kilobases. Because the additional p53 gene is expressed from its own promoter, the transgenically expressed p53 seems to be regulated in the same fashion as endogenous p53.
Increased p53 expression under the endogenous promoter protects “super p53” mice from tumorigenesis without the undesirable effects of premature aging.
https://www.sciencedirect.com/science/article/pii/S153561080...
>Garcia-Cao and collaborators report the generation of novel transgenic mice, called “super p53.” The super p53 mice express wild-type endogenous p53, and also carry one or two extra copies of a normal p53 gene, inserted as transgenes in the form of large genomic fragments of 130 to 175 kilobases. Because the additional p53 gene is expressed from its own promoter, the transgenically expressed p53 seems to be regulated in the same fashion as endogenous p53.